Title: USA's EPA awards more than $US 3 million to researchers studying how chemical exposures impact brain development
[EPA 12/02/14] — The U.S. Environmental Protection Agency (EPA) has announced over $3 million in grants to research institutions to better understand how chemicals interact with biological processes and how these interactions may lead to altered brain development. The studies are focused on improving EPA’s ability to predict the potential health effects of chemical exposures. “This research will transform our understanding of how exposure to chemicals during sensitive lifestages affects the development of the brain,” said Lek Kadeli, acting assistant administrator for EPA’s Office of Research and Development. “By better predicting whether chemicals have the potential to impact health and human development, these grants will not only advance the science necessary to improve chemical safety but protect the well being and futures of children in this nation.” These grants focus on developing better adverse outcome pathways (AOPs), which are models that predict the connection between exposures and the chain of events that lead to an unwanted health effect. AOPs combine vast amounts of data from different sources to depict the complex interactions of chemicals with biological processes, and then extend this information to explain an adverse health effect. EPA expects to use the knowledge gained from this research to develop efficient and cost-effective models to better predict if and how exposure to environmental chemicals may lead to developmental neurotoxicity. Comment